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  • Human biomimetic liver microphysiology systems (MPS)

    Category
    Title
    Human biomimetic liver microphysiology systems in drug development and precision medicine.
    Date
    December 19, 2020
    Authors
    Gough A, Soto-Gutierrez A, Vernetti L, Ebrahimkhani MR, Stern AM, Taylor DL
    Citation
    Nat Rev Gastroenterol Hepatol. 2020. Epub 2020/12/19. doi: 10.1038/s41575-020-00386-1. PubMed PMID: 33335282.
    Journal
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  • Harnessing Microphysiology Systems for Quantitative Pharmacology Models

    Category
    Title
    Harnessing Human Microphysiology Systems as Key Experimental Models for Quantitative Systems Pharmacology
    Date
    2019
    Authors
    Taylor DL, Gough A, Schurdak ME, Vernetti L, Chennubhotla CS, Lefever D, Pei F, Faeder JR, Lezon TR, Stern AM, Bahar I
    Citation
    Handbook of Experimental Pharmacology: Springer; 2019. pp. 327-67.
    Journal
    Link to Journal

  • Glass-based human liver system

    Category
    Title
    A glass-based, continuously zonated and vascularized human liver acinus microphysiological system (VLAMPS) designed for experimental modeling of diseases and ADME/TOX.
    Date
    2018
    Authors
    Li X, George SM, Vernetti L, Gough AH, Taylor DL
    Citation
    Lab on a chip. 2018;18(17):2614-31. doi: 10.1039/c8lc00418h. PubMed PMID: 30063238; PMCID: 6113686.
    Journal
    Link to Journal

  • Oxygen Tension Control Enables Zone-Specific Liver Functions in Microphysiology Systems

    Category
    Title
    Control of Oxygen Tension Recapitulates Zone-Specific Functions in Human Liver Microphysiology Systems
    Date
    2017
    Authors
    Lee-Montiel FT, George SM, Gough AH, Sharma AD, Wu J, DeBiasio R, Vernetti LA, Taylor DL
    Citation
    Experimental Biology and Medicine. 2017;242(16):1617-32. doi: 10.1177/1535370217703978. PubMed PMID: 28409533.
    Journal
    Link to Journal

  • Investigating Liver Metabolic Zonation Using Microphysiology Systems

    Category
    Title
    Pre-clinical and Clinical Investigations of Metabolic Zonation in Liver Diseases: The Potential of Microphysiology Systems
    Date
    2017
    Authors
    Soto-Gutierrez A, Gough A, Vernetti LA, Taylor DL, Monga SP.
    Citation
    Experimental Biology and Medicine. 2017:1535370217707731. doi: 10.1177/1535370217707731. PubMed PMID: 28467181.
    Journal
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  • Functional Coupling of Human Organs in Microphysiology Systems for Research

    Category
    Title
    Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle
    Date
    2017
    Authors
    Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL
    Citation
    Scientific Reports. 2017;7:42296. doi: 10.1038/srep42296. PubMed PMID: 28176881; PMCID: 5296733.
    Journal
    Link to Journal

  • Human liver investigation

    Category
    Title
    A human liver microphysiology platform for investigating physiology, drug safety, and disease models.
    Date
    2016
    Authors
    Vernetti LA, Senutovitch N, Boltz R, DeBiasio R, Shun TY, Gough A, Taylor DL
    Citation
    Experimental biology and medicine. 2016;241(1):101-14. doi: 10.1177/1535370215592121. PubMed PMID: 26202373; PMCID: 4723301
    Journal
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