News
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Dr. Mark Miedel presented Patient-specific Microphysiology Systems as an Innovative Precision Medicine Platform for Metabolic-Dysfunction Associated Steatotic Liver Disease at the 23rd NIH MPS World Summit being held in Seattle, WA June 9-14, 2024
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Dr. Mark Schurdak presented Qualification of Patient-derived Biomimetic Liver MPS as Drug Development Tools for Drug Metabolism, Toxicity, Drug Efficacy Testing, and Clinical Trial Cohort Selection at the 23rd NIH MPS World Summit being held in Seattle, Washington June 9-14, 2024
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Mengying (Summer) Xia presented a poster Toward Precision Medicine for Metabolic Dysfunction-Associated Steatotic Liver Disease Comparing Wildtype and a High-Risk PNPLA3 Variant in a Human Biomimetic Liver Microphysiology System at the 23rd NIH MPS World Summit being held in Seattle, Washington June 9-14, 2024
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Dr. Mark Schurdak presented a talk “’Show Me the Reproducibility!’ Data Management Best Practices to Enhance Confidence in Complex MPS Models and Their Predictions” at the Society of Toxicology Annual Meeting held in Salt Lake City, Utah March 10-14, 2024.
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Title
Comparison of wild-type and high-risk PNPLA3 variants in a human biomimetic liver microphysiology system for metabolic dysfunction-associated steatotic liver disease precision therapy.Date
April 30, 2024Authors
Xia M, Varmazyad M, Pla-Palacín I, Gavlock DC, DeBiasio R, LaRocca G, Reese C, Florentino RM, Faccioli LAP, Brown JA, Vernetti LA, Schurdak M, Stern AM, Gough A, Behari J, Soto-Gutierrez A, Taylor DL and Miedel MTCitation
Cell Dev. Biol. 12:1423936. doi: 10.3389/fcell.2024.1423936 -
Title
A metabolic-dysfunction associated steatotic liver acinus biomimetic induces pancreatic islet dysfunction in a coupled microphysiology system.Date
April 30, 2024Authors
Aleman J, Ravikumar K, Wiegand C, Schurdak ME, Vernetti L, Gavlock D, Reese C, DeBiasio R, LaRocca G, Angarita YD, Gough A, Soto-Gutierrez A, Behari J, Yechoor V, Miedel MT, Stern AM, Banerjee I, Taylor DLCitation
bioRxiv. 2024. Epub 20240430. doi: 10.1101/2024.04.22.590598. PubMed PMID: 38712135; PMCID: PMC11071380. -
Title
A Quantitative Systems Pharmacology Platform Reveals NAFLD Pathophysiological States and Targeting StrategiesDate
June 24, 2022Authors
Lefever DE, Miedel MT, Pei F, DiStefano JK, Debiasio R, Shun TY, Saydmohammed M, Chikina M, Vernetti LA, Soto-Gutierrez A, Monga SP, Bataller R, Behari J, Yechoor VK, Bahar I, Gough A, Stern AM, Taylor DLCitation
Metabolites. 2022;12(6). doi: 10.3390/metabo12060528. PubMed PMID: 35736460; PMCID: PMC9227696. -
Title
Prediction of Hepatic Drug Clearance with a Human Microfluidic Four-Cell Liver Acinus Microphysiology SystemDate
September 21, 2021Authors
Sakolish C, Luo YS, Valdiviezo A, Vernetti LA, Rusyn I, Chiu WA.Citation
Toxicology. 2021;463:152954. doi: 10.1016/j.tox.2021.152954. PubMed PMID: 34543702; PMCID: PMC8585690. -
Title
Quantifying the Progression of Non-Alcoholic Fatty Liver Disease in Human Biomimetic Liver Microphysiology Systems with Fluorescent Protein BiosensorsDate
May 08, 2021Authors
Saydmohammed M, Jha A, Mahajan V, Gavlock D, Shun TY, DeBiasio R, Lefever D, Li X, Reese C, Kershaw EE, Yechoor V, Behari J, Soto-Gutierrez A, Vernetti L, Stern A, Gough A, Miedel MT, Lansing Taylor D.Citation
Experimental Biology and Medicine. 2021;246:2420-41. doi: 10.1177/15353702211009228. PubMed PMID: 33957803. -
Title
Analysis of Reproducibility and Robustness of a Human Microfluidic Four-Cell Liver Acinus Microphysiology System (LAMPS)Date
2021 (Epub 2020-12-12)Authors
Sakolish C, Reese CE, Luo YS, Valdiviezo A, Schurdak ME, Gough A, Taylor DL, Chiu WA, Vernetti LA, Rusyn I.Citation
Toxicology. 2021;448:152651. doi: 10.1016/j.tox.2020.152651. PubMed PMID: 33307106; PMCID: PMC7785655.