Glass-based human liver system
Title
A glass-based, continuously zonated and vascularized human liver acinus microphysiological system (VLAMPS) designed for experimental modeling of diseases and ADME/TOX.
A glass-based, continuously zonated and vascularized human liver acinus microphysiological system (VLAMPS) designed for experimental modeling of diseases and ADME/TOX.
Date
2018
2018
Authors
Li X, George SM, Vernetti L, Gough AH, Taylor DL
Li X, George SM, Vernetti L, Gough AH, Taylor DL
Citation
Lab on a chip. 2018;18(17):2614-31. doi: 10.1039/c8lc00418h. PubMed PMID: 30063238; PMCID: 6113686.
Lab on a chip. 2018;18(17):2614-31. doi: 10.1039/c8lc00418h. PubMed PMID: 30063238; PMCID: 6113686.
Key Points:
The article appears to describe a new technology for creating a human liver acinus microphysiological system (VLAMPS) on a glass chip. This system is designed to simulate the functions of a human liver and can be used for studying liver diseases and drug metabolism.
The system is “continuously zonated and vascularized,” meaning it mimics the natural structure of the liver with different zones and blood vessels.
The article was published in 2018 in the journal “Lab on a Chip” and is freely available to read online.
If you have any further questions about the article or the technology described, you can access the full text through the provided DOI or PubMed ID.